Types

Trimethoprim Sulfadiazine; Trimethoprim Sulfamethoxazole

Brands

Bactrim; Septra; Sulfatrim; Cotrim (Trimethoprim Sulfadiazine)
Tribrissen (Trimethoprim Sulfamethoxazole)

Description

An broad-spectrum anti-bacterial substance, used against a variety of bacterial organisms.

It is a combination of two active ingredients. Both affect a vitamin called folic acid and its activity in bacteria causing destruction of its metabolic function in the bacteria.

Uses

  • Certain urinary tract infections
  • Skin infections
  • Any secondary infections - bronchitis, pneumonia, Streptococci and some strains of Staphylococcus
  • Not effective against Mycoplasma

Dosage

  • 15mg/lb orally, twice a day (24)
  • 30 mg/kg orally or by injection twice a day (20)

Side Effects

  • Diarrhoea
  • Rash and/or itching
  • Anaphylaxis (exaggerated allergic reaction on second dose if this state develops)
  • Joint inflammation

Warnings

  • Keep rat well hydrated
  • Birth defects have been reported after this medication was given to pregnant rats (21)

Combinations

Amikacin, Gentamicin